Dr Christophe B. Michel – University of Stirling
Computational Neurosciences and Vestibular Electrophysiology
Previous experimental data indicates the hyperpolarization-activated cation (Ih) current, in the inner ear, consists of two components
(different HCN subunits) which are impossible to pharmacologically isolate.
We have first determined the ability of a recent identification algorithm to discriminate the parameters of currents composed by two components on simulated data.
We then applied this algorithm to Ih current recordings from mouse vestibular ganglion neurons. The algorithm revealed the presence of a
high-voltage-activated slow component and a low-voltage-activated fast component.
Finally, the electrophysiological significance of these two Ih components was tested individually in computational vestibular ganglion neuron models (sustained and transient), in the control case and in the presence of cAMP, an intracellular cyclic nucleotide that modulates HCN channel activity.
School of Computing Science & Digital Media, Robert Gordon University, Sir Ian Wood Building, Garthdee, Aberdeen, Conference Room N117, 12:00 – 13:00.